How are ASY1, ZYP1, and MLH1 distributed during meiosis?

During meiosis, ASY1, ZYP1, and MLH1 are distributed in different regions of the cell. ASY1 localizes mainly to the axial elements of the chromosomes during prophase I, helping to maintain the meiotic chromosome structure. ZYP1 is located at the synaptonemal complex, which holds the homologous chromosomes together during alignment. Finally, MLH1 is found at the sites of crossovers between the homologous chromosomes during late prophase I and early metaphase I. The distribution of these proteins plays a crucial role in the proper segregation of chromosomes during meiosis and subsequent formation of gametes.

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