What are potential therapeutic targets for TRP channels in GI disorders?

Transient receptor potential (TRP) channels play a crucial role in regulating gastrointestinal (GI) functions, including contraction, secretion, and visceral sensation. Thus, TRP channels are potential therapeutic targets for treating GI disorders like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gastroesophageal reflux disease (GERD). Several molecules have been identified that modulate TRP channels function, such as capsaicin, menthol, and cannabinoids. These molecules can either activate or inhibit TRP channels and have shown promising results in preclinical and clinical trials for treating GI disorders. Therefore, targeting TRP channels may provide a new therapeutic approach for managing GI disorders.

This mind map was published on 22 June 2023 and has been viewed 110 times.