How do TRP channels affect gastrointestinal function?
TRP (Transient Receptor Potential) channels play a crucial role in regulating gastrointestinal function by detecting changes in temperature, chemical signals, pressure, and pH. TRPV1, TRPM8, TRPA1, TRPV4, and TRPM5 channels are expressed in the digestive tract, and their activation affects the secretion and absorption of digestive fluids, gastric motility, mucosal defense, and inflammation. For instance, TRPV1 activation enhances acid secretion and gut motility, while TRPM5 inhibition reduces glucose-stimulated intestinal secretion. Moreover, TRPA1 and TRPV4 channels mediate the perception of noxious stimuli and inflammation in the gut wall. Thus, TRP channels represent promising therapeutic targets for the treatment of functional gastrointestinal disorders and inflammatory bowel diseases.
This mind map was published on 22 June 2023 and has been viewed 114 times.
