What is the mechanism behind paradoxical psoriasis?

Paradoxical psoriasis refers to the occurrence or worsening of psoriasis symptoms in patients who are being treated with certain medications, particularly biologics. These medications are designed to target specific molecules involved in the immune response. However, in some cases, they can cause a paradoxical reaction where psoriasis symptoms worsen or new lesions appear. The exact mechanism behind this phenomenon is not fully understood, but it is believed to involve complex interactions between the medications, the immune system, and cytokines. It is hypothesized that the drugs may disturb the delicate balance of the immune system, leading to an overactive immune response and triggering psoriasis symptoms. Further research is needed to unravel the precise mechanism and identify ways to prevent or manage paradoxical psoriasis in patients undergoing immunomodulatory therapy.

This mind map was published on 12 July 2023 and has been viewed 104 times.