What are TRPM8 channels?

TRPM8 channels are ion channels that are activated by exposure to cold temperatures, menthol, and other related compounds. These channels are expressed on sensory neurons and are responsible for detecting and responding to thermal and chemical cues. When activated, TRPM8 channels allow the flow of positively charged ions into the cell, triggering nerve impulses that convey sensations of cold, tingling, and/or burning. TRPM8 channels play a key role in controlling body temperature, sensing pain, and regulating aspects of cellular metabolism.

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