What are the potential applications of TRPM8 activation?
TRPM8, a temperature-sensitive ion channel present in sensory neurons, is activated by cooling agents like menthol and icilin. Its activation has potential therapeutic applications for treating chronic pain, migraine headaches, and inflammatory diseases like arthritis. Topical formulations containing menthol can provide temporary pain relief for conditions like muscle pain and soreness. Furthermore, TRPM8 activation stimulates brown fat thermogenesis, leading to energy expenditure and weight loss. The activation of TRPM8 can also be used to alleviate cold hypersensitivity in conditions such as Raynaud's phenomenon.
This mind map was published on 22 June 2023 and has been viewed 108 times.
