How does blocking TNF alpha affect the maturation of pDCs?

Blocking TNF alpha, a pro-inflammatory cytokine, has been shown to impact the maturation of plasmacytoid dendritic cells (pDCs). TNF alpha plays a crucial role in the activation and differentiation of various immune cells, including pDCs. By blocking TNF alpha, the maturation of pDCs becomes impaired, leading to altered immune responses. This blockade inhibits the upregulation of co-stimulatory molecules, such as CD80 and CD86, as well as the production of type I interferons (IFN-I) by pDCs. Consequently, the impaired maturation of pDCs results in compromised antigen presentation and weakened immune response, which can have significant implications in various pathological conditions, such as autoimmune diseases and cancers.

This mind map was published on 12 July 2023 and has been viewed 103 times.