Which enzymes are key in DOAC metabolism?

Direct oral anticoagulants (DOACs) are medications that work by inhibiting specific clotting factors in the blood. The key enzymes involved in the metabolism of DOACs are cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp). CYP enzymes, specifically CYP3A4 and CYP2C9, are responsible for metabolizing DOACs in the liver, while P-gp plays a role in the absorption and elimination of these medications. Understanding the role of these enzymes is crucial in determining drug interactions and optimizing the effectiveness of DOAC therapy.

This mind map was published on 4 October 2024 and has been viewed 18 times.