How is TRPM8 activated by menthol?

TRPM8 is a sensory receptor protein that is specifically activated by menthol. When menthol binds to TRPM8, it triggers a conformational change in the structure of the protein, leading to its activation. This activation results in the influx of calcium ions in the cell, which then leads to a sensation of coolness. The activation of TRPM8 by menthol is believed to occur through its interaction with specific amino acid residues on the protein's surface, which facilitate the binding and subsequent activation of the receptor. Understanding the mechanism of TRPM8 activation by menthol is crucial for developing new therapeutics for the treatment of various pain and inflammatory conditions.

This mind map was published on 23 June 2023 and has been viewed 84 times.