What happens when TRPV1 channels are activated?

TRPV1 channels, also known as vanilloid receptors, are responsible for detecting and responding to noxious stimuli such as extreme temperature, spicy foods, and inflammatory mediators. When TRPV1 channels are activated, they allow influx of calcium ions into the cell, leading to depolarization and the generation of action potentials. This activation can result in sensations of burning, pain, and thermal sensation. Additionally, TRPV1 channels are also involved in mediating inflammation and hypersensitivity, making them potential targets for pain management.

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