What conditions are associated with TRP channel dysfunction?

TRP (transient receptor potential) channels are involved in several physiological processes such as pain perception, temperature sensitivity, and signal transduction. Dysfunction of these channels is associated with various conditions like chronic pain syndromes, neurodegenerative disorders, inflammatory disorders, and cancer. For instance, mutations of TRP channels lead to disorders such as congenital blindness, familial hemiplegic migraine, and episodic ataxia. Inflammatory disorders such as arthritis, colitis, and asthma are also linked to TRP channel dysfunction since they play a critical role in inflammatory responses. In cancer, TRP channels are involved in tumor initiation, angiogenesis, and metastasis.

This mind map was published on 22 June 2023 and has been viewed 68 times.