What is the role of TNFi in the development of paradoxical psoriasis?
TNFi (Tumor Necrosis Factor inhibitors) have revolutionized the treatment of various immune-mediated diseases, including psoriasis. However, paradoxical psoriasis, a condition characterized by the occurrence or exacerbation of psoriasis in patients receiving TNFi therapy for other autoimmune conditions, has emerged as a concern. The exact mechanism by which TNFi induces paradoxical psoriasis is still unclear, but it is believed to involve the dysregulation of the immune system and the inhibition of TNF-alpha, a cytokine known to play a role in psoriasis pathogenesis. Despite its prevalence, paradoxical psoriasis can often be effectively managed with adjusted TNFi dosage or switching to an alternative therapy. Further research is needed to deepen our understanding of the underlying mechanisms and refine treatment strategies for this fascinating phenomenon.
This mind map was published on 12 July 2023 and has been viewed 121 times.
