What causes the imbalance of cytokines in paradoxical psoriasis?

The imbalance of cytokines in paradoxical psoriasis, also known as paradoxical psoriasis reaction, occurs due to a disrupted immune response. Paradoxical psoriasis is a condition where psoriasis symptoms worsen or appear for the first time in patients undergoing treatment with certain medications, such as tumor necrosis factor (TNF) inhibitors. It is believed that the cytokine imbalance in paradoxical psoriasis is a result of the medication's interference with the intricate network of immune system signaling molecules. Specifically, the inhibition of TNF leads to an upregulation of interleukin-17 (IL-17) and other pro-inflammatory cytokines, causing an immune dysregulation and exacerbation of psoriasis symptoms. The exact mechanisms underlying this cytokine imbalance are still being researched, but it is crucial to understand in order to improve treatment strategies for patients experiencing paradoxical psoriasis.

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