How does capsaicin activate TRPV1 channels?

Capsaicin activates TRPV1 (Transient receptor potential vanilloid 1) channels, which are found on the surface of nociceptors, the pain-sensing neurons. Capsaicin is a molecule that fits into a binding pocket on TRPV1 channels, causing the channel to open up and allow ions to pass through. When capsaicin binds to TRPV1 channels, it triggers a series of events that leads to the sensation of heat, pain, and inflammation. Capsaicin activates these channels by switching on their molecular receptors, which in turn stimulate electric signals and calcium influx, depending on the neuron's membrane depolarization. This mechanism of activation makes capsaicin a potent tool for studying TRPV1 channels and understanding the underlying causes of pain.

This mind map was published on 22 June 2023 and has been viewed 161 times.