Creatinine is a waste product produced by the muscles during normal bodily processes. It is primarily eliminated from the body through the kidneys via a process called glomerular filtration. Creatinine is filtered out of the blood by the glomerulus, a network of tiny blood vessels within the kidneys, and then passes through the renal tubules, where a small amount may be reabsorbed. The majority of the filtered creatinine is ultimately excreted in the urine. The elimination of creatinine serves as an important measure of kidney function, as impaired kidney function can result in a buildup of creatinine in the blood. In addition to the kidneys, a small portion of creatinine is also eliminated through sweat and gastrointestinal tract, although these routes account for a minor fraction of overall creatinine elimination.
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