What is the impact of cytokine imbalance on paradoxical psoriasis?

Paradoxical psoriasis refers to the phenomenon in which patients with autoimmune conditions such as rheumatoid arthritis or inflammatory bowel disease, who are being treated with biologic medications that suppress immune responses, develop psoriasis as a side effect. The development of paradoxical psoriasis has been linked to an imbalance in cytokines, which are small proteins involved in cell signaling and immune regulation. In this context, the suppression of specific cytokines like tumor necrosis factor (TNF)-alpha or interleukin (IL)-17 can disrupt the delicate balance of cytokines in the immune system, leading to the reactivation of psoriasis or the initiation of new psoriatic lesions. This cytokine imbalance triggers an inflammatory response, resulting in the development of psoriatic symptoms in these paradoxical cases. Understanding the impact of cytokine imbalance on paradoxical psoriasis is crucial for optimizing treatment strategies and minimizing the occurrence of adverse effects.

This mind map was published on 12 July 2023 and has been viewed 122 times.