How do TRP channels contribute to gut inflammation?

TRP channels have been found to play a key role in gut inflammation. These channels are ion channels that can be activated by various stimuli such as temperature changes, chemical irritants and mechanical forces. When TRP channels are activated in the gut, they can stimulate the release of inflammatory molecules such as cytokines and chemokines, leading to an immune response that can ultimately lead to gut inflammation. In particular, TRPV1, TRPA1, and TRPM8 channels have been implicated in this process. Additionally, TRP channels have also been shown to influence intestinal motility and barrier function, which further contribute to inflammation in the gut. Understanding the contribution of TRP channels in gut inflammation could help in developing new treatments for gut disorders such as inflammatory bowel disease.

This mind map was published on 22 June 2023 and has been viewed 115 times.