How do TRP channels contribute to neuropathic pain?

Transient receptor potential (TRP) channels are a group of ion channels located in the cell membrane that play a crucial role in several physiological processes including nociception or pain sensation. In neuropathic pain, damaged nerves activate TRP channels, resulting in the sensation of pain. The uncontrolled activation of these channels can lead to chronic pain conditions, and they are considered therapeutic targets for the treatment of neuropathic pain. The TRP channels implicated in neuropathic pain include TRPV1, TRPM2, TRPM8, and TRPA1. By understanding the mechanisms of action of these channels, it is possible to develop new therapies to alleviate chronic pain conditions.

This mind map was published on 22 June 2023 and has been viewed 115 times.