How are TRP channels involved in cardiovascular regulation?

TRP (transient receptor potential) channels are involved in cardiovascular regulation by playing a crucial role in sensory signaling, cell signaling, and ion homeostasis in the cardiovascular system. These channels are expressed in the endothelial and smooth muscle cells of blood vessels, cardiac cells, and neurons, and are activated by various stimuli, including temperature, pH, mechanical stress, and chemical signals. TRP channels, especially the TRPC family, regulate vascular tone, blood pressure, and cardiac function by modulating Ca2+ influx, potassium channels, and the release of endothelium-derived relaxing factors. The dysregulation of TRP channels has been implicated in various cardiovascular diseases, including hypertension, atherosclerosis, myocardial infarction, and arrhythmias. Thus, understanding the regulatory mechanisms of TRP channels in the cardiovascular system may provide new opportunities for therapeutic interventions.

This mind map was published on 22 June 2023 and has been viewed 105 times.