What is the relationship between TRP channels and fever?

Transient receptor potential (TRP) channels are proteins found in the cell membranes of various organisms. These channels play a role in various physiological responses, including the regulation of body temperature. Specifically, some TRP channels, such as TRPV1, are activated by external stimuli, including heat, and can trigger the release of inflammatory mediators that lead to an increase in body temperature. This effect can contribute to fever, which is a common response to infection or inflammation. In summary, TRP channels are involved in the regulation of body temperature and may be a contributing factor to fever.

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