How do TRP channels regulate cardiovascular system?

TRP (transient receptor potential) channels are involved in the regulation of various physiological processes, including the cardiovascular system. TRP channels play a crucial role in the regulation of vascular tone, blood pressure, and heart rate. They are expressed in different vascular tissue cells, such as endothelial cells, smooth muscle cells, and cardiomyocytes. TRP channels are activated by various stimuli, including temperature, mechanical stress, and chemical signals such as hormones and neurotransmitters. Upon activation, TRP channels modulate intracellular calcium levels, resulting in the contraction or relaxation of vascular smooth muscles and the regulation of blood flow. Dysfunction of TRP channels has been implicated in various cardiovascular diseases, including hypertension and heart failure, highlighting the importance of TRP channels in cardiovascular physiology and pathophysiology.

This mind map was published on 22 June 2023 and has been viewed 129 times.